Despite his rapid ascension, Plater was capable of keeping Guintoli at arm's length for three laps, only for the Supersport rider to throw it all away on lap 16 when, as he was backing his Honda into Druids, the bike got away from him and sent him tumbling down.
He was almost joined on the sidelines by Camier at the same time after the local rider entered the corner too quickly and was forced to take a frustratingly slow trip across the gravel trap.
With Harris and Plater out, and Camier delayed down to ninth position, Guintoli led for the first time, comfortably ahead of Richards and Easton, who in turn held a four second gap over a competitive dispute for what was now fourth position.
From here, Guintoli's lead would not be questioned, Richards' brief mid-race fight back eventually being reigned in by fading tyres.
It meant Guintoli was free to celebrate an outstanding victory on what is not only his debut in the BSB, but also in Superbikes as a whole. A perfect performance to show off his overtaking skills – which included one at Surtees - around one of the toughest circuits on the BSB calendar, only a poor start would blot his copybook.
Richards was satisfied to open his HM Plant account with a second place finish, having started in sixth position, while third place Easton was delighted to record his first BSB podium for Hydrex.
The battle for fourth, meanwhile, went down to the finish line and would be defined by a superb recovery from Camier, who gradually picked his way through the order, dipping his Yamaha R1 past a number of his rivals, including team-mate James Ellison, whom he passed with a fine manoeuvre at Clearways with two laps remaining.
Ellison maintained fifth to cement a reliable finish for the new Yamaha R1, just ahead of Gary Mason, who recorded a clear Cup victory with a superb run to sixth position from 12th on the grid.
The Quay Garage Honda rider had even run as high as fifth as he disputed the position with Simon Andrews, who was another to put in a stellar ride from 15th on the grid. Eventually, the injured rider slipped back to seventh, but it was a promising performance for both himself and the MSS Colchester Kawasaki team.
After a fairly quiet weekend on the SMT Honda, Jason O'Halloran showed strong race pace to gradually work his way up to eighth place, initially ahead of John Laverty, although the Buildbase rider would be demoted to 12th position with a ten second penalty after being judged to have passed a rival under the safety car.