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Formula one engines are and always were the most efficient engines, that is something that technically cannot be disputed.
A turbocharger will not make an engine more economical.
The strongest combustion that can be had using regular pump fuel is at a fuel to air ratio of 14.7:1.
The benefit of a forced induction cylinder is it can burn more fuel than a NA cylinder of course it all depends on the level of boost.
Direct injection has a fuel economy benefit over indirect injection.
Re the formula one engines, the most economical (fuel wise) are the least powerful and so the least efficient.