In the opening moto, MDK/KTM's Ryan Sipes grabbed his second BTOSports.com Holeshot Award of the season and converted the good start into a career-best third place finish.
Villopoto came out of the first corner in the top five and quickly made passes to obtain the lead and remained unchallenged. Geico Powersports Honda's Trey Canard capitalised on a season-best start to finish second.
In the final moto, Villopoto notched his fifth Holeshot Award of the season to lead flag-to-flag en route to the overall win. Canard followed with back-to-back seconds while Martin Davalos put together moto results of sixth and third to land on his first-career overall podium.
"I've won some of the Triple Crown's before," stated Villopoto, who has won the opening two rounds of the three-race Monster Energy/Kawasaki Triple Crown of Motocross. "I've never won three in a row so it'd be nice to go to Steel City and wrap it up there. Once I saw how close Trey [Canard] was, I just put my head down and put in some quick laps. Three or four laps later I was about 19 seconds ahead. I figured he fell.
"Line selection is important. Some of the ruts are tricky. I probably ride the outside more than other people and it works for me. There is no chance I will ride a 450cc. I don't think I'd want to jump up and not have any idea of how well I could do. I'm sure I'd be a little off the pace and unable to ride two motos."
Villopoto now has a 95-point advantage over Rockstar/Makita Suzuki's Ryan Dungey.