After suffering his first non-finish since 2007 when he crashed out of Sunday's Indianapolis Grand Prix, Valentino Rossi needs to 'hit back at home' during this weekend's Misano round.

Rossi had a secure 50 point lead at the top of the MotoGP World Championship heading into Indy, but a fall while chasing Fiat Yamaha team-mate and title rival Jorge Lorenzo halved that advantage.

The crash damage forced Rossi's first retirement since Valencia 2007 and his first non-finish due to rider error since that season's German Grand Prix, 38 races ago.

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Having seen his seven-year Italian Grand Prix reign end at Mugello earlier in the season, when he was beaten by both Lorenzo and Ducati's race winner Casey Stoner, this weekend's second Italian event - labeled as the San Marino Grand Prix - will have particular significance.

Misano is just 15kms from Rossi's home town of Tavullia and he took an emphatic win there last year to the delight of his hordes of Tifosi.

"I'm glad we don't have long until the next race because I quickly want to forget the mistake of Indianapolis," admitted Rossi. "Last year at Misano was incredible, to win in front of all my fans and so close to home was a great emotion and after missing out in Mugello this year we are really focused on trying to get the best result there.

"As usual my Fan Club will make a big party there so I hope that we can give them a good show, it's always great to ride at home. As we saw last weekend, anything can happen and the championship isn't over, we have to keep working at the maximum and just try to take as many points as we can each time."

Team manager Davide Brivio believes it will be important for Rossi to quickly stamp out Lorenzo's momentum.

"25 points isn't much when our rivals are this strong, so we need to hit back at our home race this weekend with a good result," he said.