Casey Stoner may have taken seven laps to reach the front of Sunday's Indianapolis MotoGP, but the Australian's authority was never in serious doubt as he romped to his seventh win of the season and 30th of his career.
Repsol Honda team-mate Dani Pedrosa had been one-second slower than Stoner in qualifying, but led the early laps before finishing 4.8sec behind the world championship leader.
Home star Ben Spies may have dropped from second on the grid to third at the flag, but he rode an impressive race to fight back from ninth on the opening lap and be the top Yamaha rider, ahead of team-mate Jorge Lorenzo.
In Moto2 rookie Marc Marquez narrowed Stefan Bradl's points lead further with his fifth win of the year, while Nico Terol provided the perfect response to his Brno DNF with a massive victory in the 125cc race.
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