Jorge Lorenzo took a huge step towards the MotoGP crown at Misano after capitalizing on key title rival Dani Pedrosa's misfortune to open a 38-point championship lead.

Lorenzo was gifted a straightforward victory on his Factory Yamaha after the luckless Pedrosa was taken out by Hector Barbera on the opening lap of the race.

The 2010 world champion is now hot favourite to claim a second premier class title after wrapping up his sixth victory of the season on the YZR-M1, which looked resplendent in a new manufacturer 'Race Blu' livery at the San Marino Grand Prix.

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Lorenzo - who was never troubled throughout the shortened 26-lap race in Italy - conceded that his arch-rival had been "really unfortunate," but admitted he was now feeling "more calm" about his championship prospects.

The Spaniard, who suffered a similar fate at the hands of Alvaro Bautista at Assen, said: "It's been a very tough weekend because Dani and I have been very close in the qualifying and the warm-up.

"Unfortunately today he had really bad luck, first with the lights at the beginning of the race and then Hector took him out.

"This was really unfortunate for him. In Holland we were unlucky and today he was unlucky, anything can happen in these races," added Lorenzo, who was narrowly beaten by Pedrosa in a thrilling final lap duel at Brno in the Czech Republic at the previous round.

"We have to be happy with our result and the point advantage we now have, for sure we are much more calm now than before the race."

Describing a 'difficult" build-up to the race, with the opening day of practice was thwarted by poor weather, Lorenzo revealed he almost bit the dust himself in turn one this afternoon.

"The race was difficult for everyone, only having qualifying was not enough when you have to set up the chassis and electronics and everything for the race," he said.

"It was hotter during the race so there was less grip too. I almost crashed in turn one but managed to save it too."