"With these new appointments and the 2013 riders announced in MotoGP and World Superbike, we are well prepared to move forward into the new racing season," said the CEO of Ducati Motor Holding, Gabriele Del Torchio.
"We are confident that with this new organisation and focused strategy, we will achieve our targets and continue with the fundamentally important transfer of 'know-how' from racing into production, an element that characterises every Ducati motorcycle."'
Preziosi's Desmosedici, featuring a steel trellis frame, made its MotoGP debut in 2003, winning its sixth race with Loris Capirossi.
Capirossi took a further five wins on the 990cc bike, and a best of third overall in the 2006 championship, with Troy Bayliss adding a further victory as a one-off replacement for the injured Sete Gibernau at Valencia '06.
New signing Casey Stoner then won 23 races and the 2007 world title during four years on the 800cc machine, which saw increasing structural use of carbon fibre, but the only other post-2006 victory has been a single wet/dry win for Capirossi at Motegi '07.
Ducati has not won a race since Stoner's departure for Honda at the end of 2010, despite signing superstar Rossi to replace the Australian.
Rossi is moving back to Yamaha after just three podiums with Ducati, which switched to a twin-spar aluminium frame - as used by the Japanese bikes - for the start of the 2012 season.
Rossi admitted that, despite all the technical changes, they made little impact in terms of solving the understeer/front end problems he felt during his very first test with the Desmosedici.
Italian Andrea Dovizioso is to replace Rossi next season, alongside the retained Nicky Hayden.