Rookie Marc Marquez fired a further warning shot to his title rivals with a peerless performance in opening practice for the Indianapolis MotoGP.

The young Repsol Honda star, winner of the last two races, concluded his first ever MotoGP track session at the unique infield circuit with a 0.3s advantage over Cal Crutchlow.

Englishman Crutchlow, newly confirmed at Ducati for 2014, popped into second place as the chequered flag was waved.

Prior to the Monster Yamaha Tech 3 rider's late effort, Marquez had been 0.480s clear of Factory Yamaha's reigning champion Jorge Lorenzo, who finished the session in third.

Triple MotoGP race winner Marquez starts this weekend with a 16 point lead over team-mate Dani Pedrosa and a 26 point advantage over Lorenzo. Marquez's best FP1 lap time was 1.7s behind the official race lap record, set by Pedrosa last season.

Pedrosa and Lorenzo have used the summer break to rebuild their fitness from collarbone injuries. Their fractures are yet to fully heal, but both are much stronger than a month ago at Laguna Seca, when they braved the pain to claim fifth (Pedrosa) and sixth (Lorenzo) places.

Lorenzo, riding with a special Green Mamba snake helmet, led the session at the halfway stage before Marquez took control. Pedrosa made a more discreet start to the weekend, finishing in seventh place and 0.8s behind Marquez.

Between Lorenzo and Pedrosa on the timesheets were Stefan Bradl, Valentino Rossi and Alvaro Bautista.

Laguna Seca debut pole and podium finisher Bradl - newly confirmed at LCR Honda for 2014 - had led the session on several occasions, but was ultimately left 0.6s from Marquez. Factory Yamaha star Rossi and Gresini Honda's Bautista were both within one-tenth of Bradl.

Behind Pedrosa, factory Ducati team-mates Andrea Dovizioso and Nicky Hayden, plus Tech 3 rookie Bradley Smith, completed a top ten covered by 1.6s.

Spots of rain during the previous Moto3 practice session raised the risk levels this morning - the three different types of asphalt present around the rarely-used circuit notorious for catching out riders even in the dry.

First to fall this weekend was Karel Abraham, who highsided from his Cardion AB Aprilia after ten minutes. The Czech was carried away on a stretcher, before undergoing treatment in the Medical Centre for a 'suspected left shoulder injury'.

Pramac Ducati riders Ben Spies and Andrea Iannone both made their return from injury this morning.

Rookie Iannone missed the previous Laguna Seca round due to a dislocated shoulder at the Sachsenring, while Spies - who underwent major shoulder surgery after an accident in last October's Malaysian GP - was last on track at June's Mugello event and hasn't raced since round two in Texas.

Spies was eleventh quickest this morning (+1.726s) and Iannone twelfth (+1.964s). Aspar's Aleix Espargaro was a fraction slower as the top CRT rider.

American Blake Young is making his third wild-card appearance of the year with Attack Performance Racing. Young was 25th and last this morning, 6.9s from Marquez and 2.0s from next slowest Michael Laverty (PBM), making his Indianapolis debut.

Free practice (1):
1. Marc Marquez
2. Cal Crutchlow
3. Jorge Lorenzo
4. Stefan Bradl
5. Valentino Rossi
6. Alvaro Bautista
7. Dani Pedrosa
8. Andrea Dovizioso
9. Nicky Hayden
10. Bradley Smith
11. Ben Spies
12. Andrea Iannone
13. Aleix Espargaro
14. Yonny Hernandez
15. Colin Edwards
16. Karel Abraham
17. Randy De Puniet
18. Claudio Corti
19. Danilo Petrucci
20. Hiroshi Aoyama
21. Hector Barbera
22. Lukas Pesek
23. Bryan Staring
24. Michael Laverty
25. Blake Young

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