Winner at Misano for the past two seasons, and riding with the aid of a seamless shift gearbox for the first time, Jorge Lorenzo found himself facing unexpected set-up issues during Friday practice.

The reigning double world champion, winner last time out at Silverstone, slipped from third to fourth quickest during the two sessions - team-mate Valentino Rossi moving ahead in the afternoon.

However Lorenzo was less than three tenths from the top of the timesheets, led by Repsol Honda riders Marc Marquez and Dani Pedrosa.

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"We are having some problems to find the best set-up on the bike because I felt a little bit worse than the last years here, but we are trying to improve it," said Lorenzo.

"I'm really happy to have the new gearbox. It is working well, it's faster and more easy.

"But it's not all about the seamless. At the moment we are a little behind the Hondas but I'm very motivated and confident we can go faster tomorrow."

"We need to fix some things on the bike to find a little more confidence on entry and also rear grip is a bit of an issue," explained team manager Wilco Zeelenberg. "We need to find a couple of tenths of a second but I think we can definitely do that."

With six rounds to go, Lorenzo is nine points from Dani Pedrosa and 39 behind Marc Marquez.