Team Calvo's Isaac Vinales finished a rain interupted second Moto3 practice at Indianapolis on top of the timesheets after a determined final run saw a time of 1m 42.507s.

After a damp first session, the Moto3 bikes continued to get to grips with the new surface and track layout.

A flurry of mid-session showers pushed all the track action to the end of the session when a visibly happy Vinales snatched the top time aboard his KTM as one of the final riders to cross the famous yard of bricks.

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That lap nudged fellow Spaniard Alex Marquez into second, the Estrella Galicia rider having claimed the top spot himself seconds earlier with a time just 0.097 slower on his Honda.

Championship leader Jack Miller had come into the session on top having easily outpaced his rivals in FP1 for Red Bull KTM Ajo and was the first man to set a sub 1m 43s second time, leaving the Australian third overall on Friday.

Efren Vazquez also improved as the chequered flag was waving to finish the opening day fourth for SaxoPrint-RTG, just one place ahead of his British team-mate John McPhee in fifth,who soared up the places following a fast Brad Binder.

Rookie Enea Bastianini was sixth for Junior Team Go & Fun, Mahindra's Binder took seventh, continuing an improved performance for the Indian manufacturer which lead to a best finish of second for both the team and the South African at the Sachsenring.

Niccolo Antonelli placed the second Go & Fun bike in eighth, a readjusted Danny Kent appeared more confident and settled in ninth for Husqvarna, while Alexis Masbou was the final rider to slip inside the top ten for Ongetta-Rivacold.

Title challengers Romano Fenati and Alex Rins looked less comfortable with the alterations and conditions both only moving into 11th and 12th respectively in the closing seconds.

Jorge Navarro continued a solid debut for the Marc VDS team, Livio Loi's replacement improving his time along with the rest of the field for 22nd in the second session.