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MotoGP champion Marc Marquez moved to the head of the timesheets during second free practice at Indianapolis.
Fifth in a morning session led by Yamaha's Valentino Rossi, Marquez had spoken of the more flowing corner modifications as being less suited to his Repsol Honda than the previous stop-go format.
But the Spaniard, seeking a perfect tenth victory of the season on Sunday, showed few signs of trouble as he became the first rider into the 1m 33s early in the 45-minutes, then the first to break the 1m 32 barrier in the closing stages.
Marquez finished 0.222s clear of Pramac's Andrea Iannone, who led an all-Ducati top three as the final five minutes began.
Iannone, Andrea Dovizioso and Yonny Hernandez towed their way to the front while following in a pack behind Rossi, but were later broken up by Yamaha's Jorge Lorenzo (third), Marquez's team-mate Dani Pedrosa (fifth) and LCR Honda's Stefan Bradl (sixth).
That left Forward Yamaha's Aleix Espargaro, Rossi and Tech 3 Yamaha's Bradley Smith to complete the top ten.
While Pedrosa and Bradl - who saved several moments in FP2 - made big gains from 16th and 14th respectively in FP1, Rossi and Smith went in the other direction from first and second. Smith's team-mate Pol Espargaro also lost ground for eleventh, but was only 0.808s from Marquez.
Scott Redding was another unable to repeat his morning heroics, when he had been the top Open class rider in seventh. However twelfth place meant Redding remained the leading RCV1000R rider, ahead of the factory machines of Ducati's Cal Crutchlow and Gresini team-mate Alvaro Bautista.
Lone American rider Colin Edwards slipped from eleventh to 16th for Forward Yamaha as speculation mounts over how many of the post-Indy events he will attend.
Leon Camier, replacing the injured Nicky Hayden at Drive 7 Aspar, produced an excellent second ever MotoGP session. The Englishman slashed the gap to the top from 5.4s to 3.5s and was 0.453s from PBM regular Broc Parkes.
The corner changes and new infield asphalt allowed Marquez to lap five seconds under the previous pole record.
Free Practice 2:
1. Marc Marquez
2. Andrea Iannone
3. Jorge Lorenzo
4. Andrea Dovizioso
5. Dani Pedrosa
6. Stefan Bradl
7. Yonny Hernandez
8. Aleix Espargaro
9. Valentino Rossi
10. Bradley Smith
11. Pol Espargaro
12. Scott Redding
13. Cal Crutchlow
14. Alvaro Bautista
15. Karel Abraham
16. Colin Edwards
17. Hiroshi Aoyama
18. Hector Barbera
19. Michael Laverty
20. Danilo Petrucci
21. Mike Di Meglio
22. Broc Parkes
23. Leon Camier