Jorge Lorenzo may have won the last three races in a row, and Yamaha five of this year's six events, but the Spaniard's team manager Wilco Zeelenberg isn't taking anything for granted.

"The championship is long and they are all taking risks so you cannot say it is over for Marc [Marquez]," explained the Dutchman.

"Next race we have different tyre [options] and then maybe their problems are fixed. Each race you need to be adjusting yourself to the tyres and if the rest do that better than you, you struggle."

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Marquez, Honda's reigning double champion, has dropped 49 points behind title leader Valentino Rossi after a second DNF last weekend in Italy.

The young Spaniard is chasing improved corner entry grip from his RCV. Zeelenberg, himself a 250GP race winner, stressed the importance of getting on top of problems as they arise and not making big changes between events.

"It's very dangerous to fix problems for other races," Zeelenberg said. "You need to fix at that race weekend. If you cannot and you start to change things for the next weekend then maybe you go in the wrong direction."

Meanwhile, Lorenzo is now just six points from Rossi after a dominant performance at Mugello. Marquez and Ducati's Andrea Iannone were close to Lorenzo in the early stages, but ultimately couldn't match the pace of the #99.

"With the fresh tyre they [Marc and Iannone] had the pace, but when the freshness of the first few laps is gone, the rhythm starts and they dropped too much," Zeelenberg said.

Round seven of 18 will be at Catalunya next weekend, the home event for Marquez, Lorenzo and Dani Pedrosa.