Stefan Bradl's right scaphoid fracture at Assen has ruled the German out of his home round at the Sachsenring this weekend.
The Forward Yamaha rider, who required surgery for the injury, will be replaced by Claudio Corti.
One round before his injury Bradl had claimed eighth place at Catalunya, which is the best result by an Open rider this season.
"It's really a shame to be forced to miss my home Grand Prix, but doctors have advised me not to rush the recovery in order not to jeopardize the rest of the season,” Bradl said.
“My hand is still sore and I will try to take full advantage of the four-week break before the race at Indianapolis. I will be at Sachsenring with the team to meet my commitments with the media, the sponsors and all my fans who have been really close to me during the week after I had surgery."
Corti will be returning to the team with which he spent his only MotoGP season in 2013, riding an FTR-Kawasaki alongside Colin Edwards.
"I can't hide to be really happy to be back riding a MotoGP,” said Corti, who has also completed three Moto2 seasons and raced for MV Agusta in WSBK last year. “Many thanks to Giovanni and all the team for this opportunity and I hope Stefan will be back as soon as possible. I will try to repay the trust working hard and doing my best on the track. Riding this bike will be a new experience but I feel ready and I hope to collect a good result".
Corti, who will ride alongside Loris Baz, is the second injury replacement on the Sachsenring grid, with Honda test rider Hiroshi Aoyama standing-in for Karel Abraham (AB Motoracing).