Repsol riders Jorge Navarro and Fabio Quartararo endured a nightmare day on Friday with both involved in heavy spills.

Navarro came off at Turn 12 on the Estrella Galicia 0,0 Honda on only his third lap in morning practice and was struck by another machine, causing a red flag situation.

He sustained an abrasion to his neck an back but as a result of the blow that he received to his head, Navarro is due to undergo tests at Cesena Hospital to determine whether or not he can be passed fit to compete on Saturday.

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Quartararo, who was sixth fastest in the morning, fractured his right ankle after a fall at Turn 14 in FP2 and the Frenchman is set to undergo surgery on Saturday at the Hospital Universitario Quiron Dexeus in Barcelona, ruling him out for the remainder of the weekend.

"The crash this afternoon was a shame, because in the first practice this morning I felt very good on the bike," said Quartararo.

"We arrived at Misano with a good base after the test at Aragon and I went out on track very motivated. However, at the start of the second free practice, I lost the rear when accelerating out of Turn 14 and was thrown off.

"I was taken to the circuit medical centre and, after examining me, they told me there was a fracture to my right foot," he explained.

"These are things that happen in racing, so now we are going to Barcelona to recover as soon as possible."

Navarro, meanwhile, apologised to Lorenzo Dalla Porta after colliding with the Italian when he crashed out.

"I was looking forward to the San Marino Grand Prix and when I went out on track in the first practice, the bike lost the front when I was going into Turn 12 and I crashed," he said.

"The doctors have told me that I don't have any fractures, just some bruises from the fall and an abrasion on my neck and back. In the crash I hit Dalla Porta, for which I apologise for the incident.

"Luckily there were no major consequences for him or for me. We shall see if we can go out again tomorrow."

The team's third rider, Maria Herrera, was 32nd fastest overall on the Laglisse Factory Husqvarna.