Repsol Honda's Marc Marquez has ruled out his slim chances of retaining his MotoGP World title after closing the gap at the top of the standings with victory in Misano.

Marquez bagged all 25 points as series leader Valentino Rossi finished fifth, while Jorge Lorenzo leaves San Marino empty-handed after a high-speed accident late in the race.

Rossi is 63 points clear of Marquez, who remains in third place in the championship table, 40 points behind Lorenzo.

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With five rounds remaining, Marquez says his result in Italy has made no difference to his prospects of an unlikely title triumph.

"The gap is too far, the gap is too big," Marquez said. "Today, Lorenzo did a mistake but again he was the fastest guy on the track for me, especially in dry conditions. In the wet, Valentino was faster but 63 points are too much for five races remaining.

"My target is to try to win these five races and I will push my one hundred per cent and try to prepare for next season, but for me if I can win these five races it will be enough at the end of the season."

Marquez outsmarted the Yamaha pair with his second pit stop to change to his dry bike as Rossi and Lorenzo remained on the track on worn wets and the two-time MotoGP champion said he learned the lessons of his error at Aragon in 2014, when he crashed out after trying to remain on track with slick tyres in the damp.

"It was difficult to think on the bike because you arrive on the limit, you must think how many seconds is the other rider [in front or behind], how is the track, how many laps remain and trying to calculate the lap time and what you can do on wet and dry tyres," he said.

"In Aragon last year I did a mistake in these conditions, so this year I tried to learn always about these situations and I learned many things from Aragon and I say, okay, if it happens like this, we will try to avoid [another miscalculation].

"On the first time we changed the bike when the others changed, but then on the second time it was more clear to change the bike like in Assen last year," he added.

"On wet tyres when it started to dry both Yamaha riders were faster than me. My bike was shaking on the straight and I said it was time to go in because if I continue like this, I cannot win the race.

"When I go out with the slicks I feel that the track was more dry than what I expect, so that was the key: changing the bike two laps earlier than the Yamaha riders."