Gabor Talmacsi took his second victory as the reigning 125cc world champion at Misano on Sunday, when an accident for 2008 championship leader Mike di Meglio provided the Hungarian with hope of retaining his title.
Only Bradley Smith was capable of fighting Talmacsi, the pair quickly escaping from the rest of the field with Smith shadowing the Aspar Aprilia rider until a mistake at the midway point of the 23 laps allowed the young Briton ahead.
But Talmacsi took just two laps to close down the Polaris World Aprilia rider and retook the lead with a neat inside pass with nine laps to go - just moments after di Meglio had fallen from third.
The Frenchman had fought back from a poor start to stake his claim for a podium finish, but fell from his Belsen Derbi when it bobbled over some bumps. That handed third place to nearest title rival Simone Corsi, who was soon caught by di Meglio's team-mate Joan Olive.
The pair battled right to the flag, with Corsi prising third from Olive on the very last lap - the Spaniard then falling as he attempted to respond at the final corner.
Talmacsi won by 5.4secs from Smith, who equalled his career-best grand prix finish, having also claiming second position in the French Grand Prix.
Talmacsi, who began the race 64 points from di Meglio, has now closed to 39 points behind, while Corsi has advanced from 44 points to 28 from di Meglio with five rounds still to go.
Race results - Misano:
1. Talmacsi (Aprilia)
2. Smith (Aprilia) +5.402secs
3. Corsi (Aprilia) +14.388secs
4. Marquez (KTM) +17.058secs
5. Terol (Aprilia) +17.321secs
6. Iannone (Aprilia) +17.482secs
7. Cortese (Aprilia) +17.485secs
8. Aergerter (Derbi) +18.657secs
9. Rabat (KTM) +19.148secs
10. Gadea (Aprilia) +34.650secs
14. Webb (Aprilia) +53.241secs
Redding (Aprilia) DNF