Following this morning's rain shower, the weather was dry but overcast for the race, reducing the track temperature by 12 degrees relative to the scorching 52-degrees seen in Saturday's qualifying.
Tyre choice had been borderline between the hard or soft rear slick, but the cooler weather - a possibility of further light rain - made the softer option already favoured by the Yamaha riders less of a gamble.
Ultimately, the front row of Stoner, Lorenzo and Crutchlow picked the hard/soft/soft rear respectively, while the second row of Spies, Pedrosa and Dovizioso selected the soft/hard/soft options.
Of the top six, only the Honda riders were running the older spec hard front.
The unlucky Spies charged all the way from last to tenth after his fall.
Alvaro Bautista (Honda), Valentino Rossi
(Ducati), Stefan Bradl (Honda) and Nicky Hayden
(Ducati) finished between Crutchlow and Spies.
Karel Abraham become the final full time rider to score a point this year in a distant twelfth place for Cardion AB Ducati.
Local star Aleix Espargaro beat Gresini FTR's Michele Pirro and his Aspar Aprilia team-mate Randy de Puniet
to be the top CRT rider in 13th.
de Puniet was the only CRT rider to choose the harder rear.
Colin Edwards, making his return after missing Le Mans with a broken collarbone, was the only rider not to be classified after finishing through the pits on his Suter-BMW.
An official port-race test will take place back at Catalunya on Monday, with another test at Aragon on Wednesday (in place of the cancelled Estoril test).
Round six of the MotoGP World Championship will then be held at Silverstone from June 15-17.
Catalan Grand Prix:
1. Jorge Lorenzo
2. Dani Pedrosa
3. Andrea Dovizioso
4. Casey Stoner
5. Cal Crutchlow
6. Alvaro Bautista
7. Valentino Rossi
8. Stefan Bradl
9. Nicky Hayden
10. Ben Spies
11. Hector Barbera
12. Karel Abraham
13. Aleix Espargaro
14. Michele Pirro
15. Randy De Puniet
16. James Ellison
17. Mattia Pasini
18. Yonny Hernandez
19. Danilo Petrucci
20. Ivan Silva