MotoGP world champion Jorge Lorenzo won his third race of the season with a dominant performable at Misano on Sunday.
Defying spots of rain on the grid, Lorenzo snatched the lead with a firm pass on title leader and pole-sitter Casey Stoner at turn one.
The Yamaha star then absorbed constant pressure from the Repsol Honda rider for the first half of the race - after which Stoner began unexpectedly dropping back.
Stoner later revealed that he was simply physically exhausted – not having slept well since last Sunday's Indianapolis round - and just didn't have the strength to push as hard as he wanted to.
Lorenzo remained wheel-perfect to the chequered flag to win his first race since Mugello by 7.299sec and reduce Stoner's points lead from 44 to 35 with five rounds to go.
The nine-point change was because it wasn't Stoner finishing in second, but his team-mate Dani Pedrosa.
Third on the grid Pedrosa had dropped back from the leading pair during the first half of the race. Stoner's loss of pace then saw Pedrosa close quickly on the Australian and he wasted no time in drafting past along the back straight with six laps to go.
Stoner - winner of seven races this season, including the previous three events - was thus left to collect the final podium place, 11.967sec from victory.
The highlight of the closing stages was a thrilling three-way fight between Marco Simoncelli, Andrea Dovizioso and Ben Spies for fourth.
Repsol rider Dovizioso did all he could to pass fellow Italian Simoncelli, but the Gresini Honda star thwarted his every effort. The trio were side-by-side into a braking zone on the final lap, but it was Simoncelli who held his line and regained fourth on the exit.
The #58 took fourth by 0.037sec from Dovizioso, with Factory Yamaha rider Spies, seventh early in the race, just 0.702sec further behind.