Amongst the crop of newcomers to Macau are exciting road racing talent Lee Johnston, 28, making his debut along with RPM Performance team mate Jamie Hamilton.
Johnston impressed on his Isle of Man TT debut earlier this year, but really marked himself out as a potential star of the roads at the Ulster GP where he won the National and Challenge races, before finishing an impressive third in the Supersport race.
Twenty-one-year-old Hamilton, meanwhile, was the leading Isle of Man TT newcomer this year and has just completed a successful Irish road racing season.
From the USA comes perennial Macau favourite Mark Miller, this year aboard a Splitlath Redmond Aprilia, with fellow American Brandon Cretu, 27, making his Guia Circuit debut on a Hel Performance Honda.
Cretu is the youngest American rider ever to compete at Isle of Man, and has contested WERA Endurance championships in the US. Joining Miller on the Splitlath Redmond team is David Johnson of Australia.
Amongst the truly international field are newcomers Italian Stefano Bonetti, third in the Isle of Man TT Privateers Championship, Japanese rider Yoshinari Matsuhita and Brazilian Rafael Paschoalin. Paschoalin, from Sao Paulo, won the 2008 Brazilian Supermoto Championship, and the 500 Miles of Interlagos in 2009. This year, he was runner up at Interlagos..
From Portugal come Macau regulars Nuno Caetano on a KS Team of Portugal Suzuki, Luis Carreira with Benimoto/Rider/Cetelem, also on board a Suzuki, and Fernando Costa on a Pon Pone Squadra Ducati.
Closer to home, flying the flag for Macau will be Joao Fernandes, partnering German Rico Penzkofer at Penz 13 on a pair of BMWs, and Sou Sio Hong on a Honda.
A new Team Trophy award has also been introduced for this year. Teams with two riders are eligible to enter, with each rider receiving points in an increasing scale, with one point for the top finishing rider.
The team which collects the least number of points from both riders combined wins a trophy and prize monies.
Six manufacturers are represented in this year's entry, and for the first time a three-in-a-row grid format, as used in MotoGP, will be adopted in place of the previous four.