Relieving Marino of the lead into Roggia, Sofuoglu forged an early advantage as Lowes contended with attention from the Kawasaki and Honda contingent that were evidently quicker in the straight line.
However, just when it looked like Sofuoglu was heading for an easy passage to victory, the Turk would low-side on the exit of the second Lesmo on lap four. Though he would remount with a view to continuing, Sofuoglu would retire to the pit lane, leaving him to rue a potentially crucial missed opportunity.
Opening the door for Lowes, the Yakhnich Yamaha rider still found himself in a perilous position, his YZF-R6 noticeably slower in a straight line even without taking his wrist injury into account. As such, Marino would repeatedly draft by on the straight aboard his Kawasaki, only for Lowes to get him back through the bends.
Matters would come to a head on lap eight of ten when the close-following Zanetti and Riccardo Russo began to make their presence felt too, taking full advantage of the double draft to shuffle their way into contention.
Indeed, with less than two laps to go, Lowes found himself dropped from first to fourth on the run to the first corner as a revitalised Russo blasted through into the lead, ahead of Zanetti and Marino.
Undeterred, Lowes would use the Yamaha's braking strength to simply scythe past all three bikes into the Roggia chicane, a critical move at a critical time that left Marino, Zanetti and Russo tripping over one another in response.
As such, when Lowes entered the final lap, only Zanetti was close enough to speed past, but Lowes would simply respond by out-braking him into turn one to nose back ahead.
Even when Marino out-braked himself into Roggia, taking him past Lowes and out wide, the Briton would coolly allow him through before cutting back underneath him.
Eking out the advantage he needed, Lowes would be relatively unchallenged over the remainder of the lap, cruising across the line to complete a hard fought second win of the year on what became a remarkably tough day.
Furthermore, with Foret, van der Mark and Sofuoglu failing to score, Lowes now heads up the standings with 70 points, 16 points clear of his nearest rival.