Jorge Lorenzo has won the Italian MotoGP for the third successive season, breaking away from his Honda rivals at half-distance to claim Yamaha's first victory since round one in Qatar.

Inured rookie Marc Marquez looked set to claim an impressive second, overtaking Repsol team-mate Dani Pedrosa with five laps remaining - but threw away his perfect MotoGP podium form by sliding off with just three laps to go.

The put title leader Pedrosa back into the runner-up spot, although he faced late pressure from Tech 3 Yamaha's Cal Crutchlow, who finished one-second from the Spaniard to complete the podium.

Stefan Bradl (Honda LCR), Andrea Dovizioso (Ducati) and Nicky Hayden (Ducati) completed the top six.

The event started in disastrous fashion for home hero Valentino Rossi, whose hopes of mounting a podium challenge ended when he and Alvaro Bautista tangled in the mid-pack after just a few turns - sending them both slamming into a tyre wall.

Footage appeared to show Bautista turn across and strike the side of Rossi - whom Bautista appears to simply not have seen - as they made a left-right transition. The Spaniard instantly fell while Rossi was sent spearing off-track with him.

Both hit the tyre wall - preceded by soft barriers - hard and were lucky to walk away.

By that time Rossi's team-mate Lorenzo was already leading, having dived under pole sitter Pedrosa on the exit of turn one - forcing Pedrosa to lift his RCV.

Lorenzo, Pedrosa and Marquez - riding battered and bruised after a huge 170mph fall on Friday - soon broke away from the rest of the field, led by Crutchlow. There was little between the leading trio by the halfway stage, but Lorenzo's pace then proved unmatchable.

Lorenzo has now moved ahead of Marquez and into second in the standings, twelve points from Pedrosa, after five of 18 events.

Top satellite rider Crutchlow is now just six points from Marquez and felt he had a fighting chance of overhauling Pedrosa for third in the race, before opting to play safe once a podium was confirmed by Marquez's exit.

Dovizioso, who injured his neck on Friday, began the race on the outside of the front row, but knew it would be a tall order to retain his place in the race. Still, the Italian battled for fourth with Bradl right to the line, losing out by just a few tenths, although the pair were some 19 seconds behind Lorenzo.

Hayden brought the second factory Desmosedici home in a lonely sixth place, with factory wild-card seventh on the 'lab' version of the GP13 after just getting the better of top CRT rider Aleix Espargaro.

After suffering two massive highsides this weekend, the first of which will require a skin graft on his finger, rookie Bradley Smith reached the chequered flag in ninth for Tech 3.

Avintia's Hector Barbera completed the top ten, with Randy de Puniet (Aspar), Danilo Petrucci (Ioda), Andrea Iannone (Pramac), Colin Edwards (Forward) and Karel Abraham (Cardion AB) also scoring.

Pramac Ducati's Ben Spies withdrew from the event on Saturday and will not return to action until he is sure that his healing shoulder is back to full strength.

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Italian MotoGP:
1. Jorge Lorenzo
2. Dani Pedrosa
3. Cal Crutchlow
4. Stefan Bradl
5. Andrea Dovizioso
6. Nicky Hayden
7.Michele Pirro
8. Aleix Espargaro
9. Bradley Smith
10. Hector Barbera
11. Randy De Puniet
12. Danilo Petrucci
13. Andrea Iannone
14. Colin Edwards
15. Karel Abraham
16. Yonny Hernandez
17. Michael Laverty
18. Bryan Staring
19. Lukas Pesek
Marc Marquez
Claudio Corti
Hiroshi Aoyama
Valentino Rossi
Alvaro Bautista