Jorge Lorenzo shaved another five points off rookie title leader Marc Marquez's MotoGP World Championship lead with a commanding victory at Misano.

Lorenzo, who started from second place on the grid, blasted into the lead on the opening lap and quickly established an advantage of almost two seconds on the Factory Racing Yamaha M1 from Repsol Honda's Dani Pedrosa.

The defending world champion was in total control as he followed up his thrilling Silverstone triumph with a less frantic success at the Misano MotoGP, taking the chequered flag with a healthy margin of three seconds from championship leader Marc Marquez.

Lorenzo is now level on 215 points with Dani Pedrosa, 34 behind Marquez with five rounds remaining.

Marquez and team-mate Pedrosa battled all the way to the line, exchanging places in the closing laps before the series rookie pulled away to cement the runner-up spot.

Valentino Rossi, who started from third place on the front row, was unable to make it onto the rostrum at his home race as the nine-time world champion finished in a lonely fourth on the second of the Factory Yamahas.

Tech 3 Racing's Cal Crutchlow and Stefan Bradl on the LCR Honda fought out an entertaining duel for fifth place, with Crutchlow holding the position for much of the race until Bradl made a decisive pass stick on the last lap of the race.

Lorenzo seized the initiative from the off, powering into the lead and immediately putting daylight between himself and Pedrosa on lap one, with pole man Marquez slotting into third.

Aleix Espargaro incurred a ride-through penalty after jumping the start, with the Power Electronics CRT rider momentarily holding fourth on lap one ahead of Rossi.

Lorenzo rattled off a series of hot laps to extend his advantage to 2.2 seconds over Pedrosa on the fourth lap, with Marquez and Rossi beginning to close up in the battle for second.

On lap five, Marquez made a costly mistake on the brakes as he attempted to pass Pedrosa at Querica, running wide and allowing Rossi through into third place.

Behind the top four, Crutchlow and Bradl were disputing fifth position, clear of Alvaro Bautista on the Gresini Honda in seventh.

Ducati trio Nicky Hayden, Andrea Dovizioso and Michele Pirro were locked in a battle of their own for eighth, with series rookie Bradley Smith battling to join them.

Lorenzo held an advantage of 2.5s at the front over Pedrosa as Marquez began to make up ground on Rossi following his mistake earlier.

On the 12th lap, Marquez pounced with a clinical move on the brakes at Tramonto, taking third place away from Rossi as he set his sights firmly on Pedrosa in second place.

True to form, Marquez relentlessly hunted down Pedrosa and the inevitable attack materialised on lap 17 as he slid underneath Pedrosa on the brakes at turn two.

Pedrosa, though, was prepared for a fight with his young rival and kept in touch with the championship leader, lining him up for a pass on lap 22 at Tramonto to re-take second place.

Marquez quickly responded, hitting back at Carro on the brakes as the pair's battle played into Lorenzo's hands, who extended his lead further at the front to more than four seconds.

Rossi's hopes of a rostrum at the Marco Simoncelli circuit were clearly over as the Italian star held a lonely fourth place.

Marquez put the hammer down and began to ease away from Pedrosa, who could do nothing this time to prevent his team-mate from opening an advantage.

The young MotoGP sensation was unable to do anything abut Lorenzo, however, who closed out his fifth victory of the season in convincing style to win by 3.3s ahead of Marquez and Pedrosa, moving level with Pedrosa on points.

Lorenzo - 34 points behind Marquez - goes ahead of Pedrosa in the championship standings based on his higher number of race wins this season.

Behind the top four, Crutchlow lost fifth place to Bradl on the final lap at Querica and had to settle for sixth, with Bautista, Dovizioso and Hayden and Pirro the top ten.

Smith finished in 11th position on the Tech 3 Yamaha, with Colin Edwards holding off a late challenge by Espargaro to finish as the leading CRT rider.

Karel Abraham was a retirement as he continues to struggle with his damaged shoulder, with Lukas Pesek pulling into the pits on lap three.

Pramac Racing's Andrea Iannone was a faller on the third lap.

Yonny Hernandez, tipped to take over Ben Spies Pramac Ducati seat for the rest of the season, also failed to finish the race on Paul Bird's CRT machine.

An official post race test will be held at Misano on Monday.

San Marino MotoGP:
1. Jorge Lorenzo
2. Marc Marquez
3. Dani Pedrosa
4. Valentino Rossi
5. Stefan Bradl
6. Cal Crutchlow
7. Alvaro Bautista
8. Andrea Dovizioso
9. Nicky Hayden
10. Michele Pirro
11. Bradley Smith
12. Colin Edwards
13. Aleix Espargaro
14. Hiroshi Aoyama
15.Danilo Petrucci
16. Claudio Corti
17. Randy De Puniet
18. Michael Laverty
Bryan Staring
Hector Barbera
Yonny Hernandez
Karel Abraham
Andrea Iannone
Lukas Pesek