Updated following official confirmation that Morbidelli will join Monster Yamaha and Dovizioso Petronas SRT, from Misano...

Factory Teams

Repsol Honda:
Marc Marquez (End of 2024)
Pol Espargaro (End of 2022)

Monster Yamaha:
Franco Morbidelli (End of 2023)
Fabio Quartararo (End of 2022)

Lenovo Ducati:
Jack Miller (End of 2022)
Francesco Bagnaia (End of 2022)

Suzuki:
Alex Rins (End of 2022)
Joan Mir (End of 2022)

Aprilia:
Aleix Espargaro (End of 2022)
Maverick Vinales (End of 2022)
Lorenzo Savadori (End of 2021)

Red Bull KTM:
Miguel Oliveira (End of 2022)
Brad Binder (End of 2024)

Independent Teams

Gresini Ducati:
Fabio di Giannantonio (End of 2022)*
Enea Bastianini (End of 2022)

Petronas Yamaha Sepang Racing Team:
Andrea Dovizioso (End of 2022, Yamaha contract)
Valentino Rossi (Yamaha contract, end of 2021)
Darryn Binder?

With Rossi retiring, Morbidelli released from the second year of his SRT contract to join the Factory team in place of Vinales, Petronas withdrawing as title sponsor and the Sepang circuit no longer involved in team ownership, the 'reborn' Malaysian squad will run Andrea Dovizioso on Morbidelli's A-Spec bike from Misano onwards, then on a factory-spec M1 for 2022. Moto3's Darryn Binder heads the list of Dovizioso's potential 2022 team-mates.

Tech3 KTM:
Remy Gardner (KTM contract, end of 2022)*
Raul Fernandez (KTM contract, end of 2022)*
Danilo Petrucci (KTM contract, end of 2021)
Iker Lecuona (KTM contract, end of 2021)

LCR Honda:
Alex Marquez (HRC contract, end of 2022)
Takaaki Nakagami (HRC contract, end of 2021 'and beyond')

Pramac Ducati:
Johann Zarco (Ducati contract, end of 2022)
Jorge Martin (Ducati contract, end of 2022)

VR46 Ducati:
Luca Marini (TBC)
Marco Bezzecchi?

Valentino Rossi's team gets its own grid places for 2022, effectively taking over the Avintia Ducati spots. VR46 will use Ducati machinery, with current rider Luca Marini (run in partnership with Avintia for his rookie season) on one of the bikes. VR46 Moto2 rider Marco Bezzecchi is tipped for the other seat.

* Rookie.